P4-093: PET amyloid imaging: Implications for estimating risk of progression to Alzheimer's disease in individuals with mild cognitive impairment
نویسندگان
چکیده
منابع مشابه
Predictive Accuracy of Amyloid Imaging for Progression From Mild Cognitive Impairment to Alzheimer Disease With Different Lengths of Follow-up
In the past decade, amyloid deposition has been shown to begin many years before the clinical symptoms of dementia in mild cognitive impairment (MCI) due to Alzheimer disease (AD). Longitudinal studies with different follow-up durations have suggested that C-Pittsburgh compound B positron emission tomography (C-PIB-PET) may play a role in stratifying patients with MCI into risk levels for devel...
متن کاملPET of brain amyloid and tau in mild cognitive impairment.
BACKGROUND Amyloid senile plaques and tau neurofibrillary tangles are neuropathological hallmarks of Alzheimer's disease that accumulate in the cortical regions of the brain in persons with mild cognitive impairment who are at risk for Alzheimer's disease. Noninvasive methods to detect these abnormal proteins are potentially useful in developing surrogate markers for drug discovery and diagnost...
متن کاملAmyloid PET imaging in patients with mild cognitive impairment: a 2-year follow-up study.
BACKGROUND Patients with amnestic mild cognitive impairment (MCI) have greater risk of conversion to Alzheimer disease (AD). Increased brain amyloid burden in AD and MCI has been demonstrated with PET using [(11)C] Pittsburgh compound B (PiB) as a tracer. OBJECTIVE To evaluate change in β-amyloid deposition in with MCI during 2-year follow-up. METHODS Patients with MCI and controls were stu...
متن کاملThe Risk of Incident Mild Cognitive Impairment and Progression to Dementia Considering Mild Cognitive Impairment Subtypes
BACKGROUND It remains unclear how demographic and clinical characteristics are related to the risk of incident mild cognitive impairment (MCI) by its subtypes. Moreover, the contribution of the subtypes of incident MCI to the progression to dementia remains puzzling. METHODS We used data collected by the National Alzheimer Coordinating Center. Our analysis sample included cognitively normal s...
متن کاملUpdate on appropriate use criteria for amyloid PET imaging: dementia experts, mild cognitive impairment, and education.
Amyloid PET imaging is a novel diagnostic test that can detect in living humans one of the two defining pathologic lesions of Alzheimer disease, amyloid-β deposition in the brain. The Amyloid Imaging Task Force of the Alzheimer's Association and Society for Nuclear Medicine and Molecular Imaging previously published appropriate use criteria for amyloid PET as an important tool for increasing th...
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ژورنال
عنوان ژورنال: Alzheimer's & Dementia
سال: 2015
ISSN: 1552-5260
DOI: 10.1016/j.jalz.2015.06.1798